| Program#/Poster#: |
694.10/M48 |
| Title: |
Norepinephrine transmission between locus coeruleus and central amygdala regulates aversive Pavlovian-to-instrumental transfer |
| Location: |
Hall A |
| Presentation Time: |
Wednesday, Oct 21, 2015, 8:00 AM -12:00 PM |
| Presenter at Poster |
Wed, Oct. 21, 2015, 9:00 AM - 10:00 AM |
| Topics: |
++F.03.g. Motivation and emotions: Fear, anxiety, and pain |
| Authors: |
*V. CAMPESE1, J. SOROETA3, E. VAZEY4, G. ASTON-JONES4, J. LEDOUX2, R. SEARS5;
1Ctr. For Neural Sci., 2New York Univ., New York, NY; 3Univ. of Arkansas, Fayettville, AR; 4Rutgers, New Brunswick, NJ; 5Nathan Kline Inst., Orangeburg, NY |
| Abstract: |
Three experiments provide evidence that norepinephrine (NE) transmission in the central amygdala (CeA) modulates Pavlovian-to-instrumental transfer (PIT). Specifically, experiment 1 demonstrated that, compared to vehicle infusions, muscimol infusions into the CeA significantly impaired PIT, confirming the role of CeA in this phenomenon. Experiment 2 found that systemic NE agonism with procaterol eliminated PIT and NE blockade with propranolol increased PIT. Using excitatory designer receptors exclusively activated by designer drugs (DREADDs) experiment 3 found that excitation of neurons in the locus coeruleus (LC) significantly impaired PIT. Generally less responding and weaker transfer were seen in these rats following treatment with clozapine-n-oxide (CNO) compared to vehicle treatment. This was also true when targeting the terminals of DREADD expressing LC neurons in the CeA with intracranial CNO infusions. Ongoing studies are evaluating the effects of LC inhibition with DREADDs on PIT. These studies provide strong evidence that NE transmission in CeA constrains PIT, which is in agreement with findings that implicate NE processes in the CeA as critical to the expression of aversive Pavlovian threat conditioning. |
| Disclosures: |
V. Campese: None. J. Soroeta: None. E. Vazey: None. G. Aston-Jones: None. J. LeDoux: None. R. Sears: None. |
| Keyword
(s): |
PAVLOVIAN CONDITIONING |
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AMYGDALA |
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LOCUS COERULEUS |
| Support: |
NIH MH38774 |
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